Comprehensive Peptide Mapping and PTM Analysis of Monoclonal Antibodies using High-Resolution Mass Spectrometry
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Biotherapeutics are complex, heterogeneous molecules produced in living cells, often from hamster, mouse, or bacterial systems. These systems are highly sensitive to variations in growth conditions, making the physical environment a critical factor in product consistency. Even minor changes can significantly impact the physicochemical properties of the final purified drug. Consequently, large-scale manufacturing processes for biotherapeutics require extensive optimization during development to ensure consistent product quality and efficacy.